产品货号：
Z37249
中文名称：
ESRRG抗体
英文名称：
Anti-ESRRG Antibody (Clone#OTI1D10)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ESRRG Antibody (Clone#OTI1D10) |
| 指标别名 | ERR gamma 2;ERR3;ERRG2;ERRgamma;ESRRG;estrogen related receptor gamma;KIAA0832;NR3B3 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IF |
| 基因名称 | ESRRG |
| 克隆号 | OTI1D10 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | Human recombinant protein fragment corresponding to amino acids 24-263 of human ESRRG(NP_001429) produced in E.coli. |
| 实际分子量 | 51.1KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | Estrogen-related receptor gamma (ERR-gamma),also known as NR3B3,is a nuclear receptor that in humans is encoded by the ESRRG gene.This gene encodes a member of the estrogen receptor-related receptor (ESRR) family,which belongs to the nuclear hormone receptor superfamily.All members of the ESRR family share an almost identical DNA binding domain,which is composed of two C4-type zinc finger motifs.The ESRR members are orphan nuclear receptors;they bind to the estrogen response element and steroidogenic factor 1 response element,and activate genes controlled by both response elements in the absence of any ligands.The ESRR family is closely related to the estrogen receptor (ER) family.They share target genes,co-regulators and promoters,and by targeting the same set of genes,the ESRRs seem to interfere with the ER-mediated estrogen response in various ways.It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters,modulates cell proliferation and estrogen signaling in breast cancer,and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation.Multiple alternatively spliced transcript variants have been identified,which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. |
| Uniprot ID | P62508 |
| 推荐稀释比 | Western blot (WB) 1:2000 Immunofluorescence (IF) 1:100 |
相关搜索：ESRRG抗体，ESRRG单抗，Anti-ESRRG Antibody (Clone#OTI1D10)